6FAZ

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.

6FAZ の概要

• エントリーDOI: 10.2210/pdb6faz/pdb
• 分子名称: Glutamate receptor 2, SULFATE ION, DI(HYDROXYETHYL)ETHER, ... (10 entities in total)
• 機能のキーワード: ampa receptor, glua2, ligand-binding domain, glua2-s1s2j, positive allosteric modulator, membrane protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60905.80

構造登録者

Nielsen, L.,Laulumaa, S.,Kastrup, J.S. (登録日: 2017-12-18, 公開日: 2018-11-21, 最終更新日: 2024-01-17)

• 主引用文献: Drapier, T.,Geubelle, P.,Bouckaert, C.,Nielsen, L.,Laulumaa, S.,Goffin, E.,Dilly, S.,Francotte, P.,Hanson, J.,Pochet, L.,Kastrup, J.S.,Pirotte, B.; Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds.; J. Med. Chem., 61:5279-5291, 2018; PubMed: 29775064; DOI: 10.1021/acs.jmedchem.8b00250

実験手法

X-RAY DIFFRACTION (1.4 Å)