6F7I

human MALT1(329-728) IN COMPLEX WITH MLT-747

6F7I の概要

• エントリーDOI: 10.2210/pdb6f7i/pdb
• 分子名称: Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 1-[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloranyl-6-pyrrolidin-1-ylcarbonyl-pyridin-3-yl)urea, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: dimer, exosite binder, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92548.23

構造登録者

Renatus, M.,Renatus, M. (登録日: 2017-12-09, 公開日: 2019-01-02, 最終更新日: 2024-05-01)

• 主引用文献: Quancard, J.,Klein, T.,Fung, S.Y.,Renatus, M.,Hughes, N.,Israel, L.,Priatel, J.J.,Kang, S.,Blank, M.A.,Viner, R.I.,Blank, J.,Schlapbach, A.,Erbel, P.,Kizhakkedathu, J.,Villard, F.,Hersperger, R.,Turvey, S.E.,Eder, J.,Bornancin, F.,Overall, C.M.; An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.; Nat. Chem. Biol., 15:304-313, 2019; PubMed: 30692685; DOI: 10.1038/s41589-018-0222-1

実験手法

X-RAY DIFFRACTION (2.43 Å)