6F7B
Crystal structure of the human Bub1 kinase domain in complex with BAY 1816032
Summary for 6F7B
Entry DOI | 10.2210/pdb6f7b/pdb |
Descriptor | Mitotic checkpoint serine/threonine-protein kinase BUB1, 2-[3,5-bis(fluoranyl)-4-[[3-[5-methoxy-4-[(3-methoxypyridin-4-yl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]ethanol, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | bub1, kinase inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42042.86 |
Authors | Holton, S.J.,Siemeister, G.,Mengel, A.,Bone, W.,Schroeder, J.,Zitzmann-Kolbe, S.,Briem, H.,Fernandez-Montalvan, A.,Prechtl, S.,Moenning, U.,von Ahsen, O.,Johanssen, J.,Cleve, A.,Puetter, V.,Hitchcock, M.,von Nussbaum, F.,Brands, M.,Mumberg, D.,Ziegelbauer, K. (deposition date: 2017-12-08, release date: 2018-12-19, Last modification date: 2021-05-05) |
Primary citation | Siemeister, G.,Mengel, A.,Fernandez-Montalvan, A.E.,Bone, W.,Schroder, J.,Zitzmann-Kolbe, S.,Briem, H.,Prechtl, S.,Holton, S.J.,Monning, U.,von Ahsen, O.,Johanssen, S.,Cleve, A.,Putter, V.,Hitchcock, M.,von Nussbaum, F.,Brands, M.,Ziegelbauer, K.,Mumberg, D. Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP InhibitorsIn VitroandIn Vivo. Clin.Cancer Res., 25:1404-1414, 2019 Cited by PubMed: 30429199DOI: 10.1158/1078-0432.CCR-18-0628 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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