6F7B
Crystal structure of the human Bub1 kinase domain in complex with BAY 1816032
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitotic checkpoint serine/threonine-protein kinase BUB1 | polymer | 361 | 41484.0 | 1 | UniProt (O43683) Pfam (PF00069) In PDB | Homo sapiens (Human) | hBUB1,BUB1A |
| 2 | A | 2-[3,5-bis(fluoranyl)-4-[[3-[5-methoxy-4-[(3-methoxypyridin-4-yl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]ethanol | non-polymer | 534.5 | 1 | Chemie (CVQ) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 726 - 1085 (UniProt: O43683)
| PDB | External Database | Details |
|---|---|---|
| Gly 725 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41484.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 558.8 | |
| All* | Total formula weight | 42042.9 |
