6F6Z

Mouse Thymidylate Synthase Cocrystallized with N(4)OHdCMP and Soaked in Methylenetetrahydrofolate

6F6Z の概要

• エントリーDOI: 10.2210/pdb6f6z/pdb
• 分子名称: Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), (2~{S})-2-[[4-[[(6~{R})-2-azanyl-4-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, ... (4 entities in total)
• 機能のキーワード: enzyme, inhibitor, cofactor, transferase
• 由来する生物種: Mus musculus (House Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71567.34

構造登録者

Wilk, P.,Jarmula, A.,Maj, P.,Rode, W. (登録日: 2017-12-06, 公開日: 2019-01-30, 最終更新日: 2024-01-17)

• 主引用文献: Maj, P.,Jarmula, A.,Wilk, P.,Prokopowicz, M.,Rypniewski, W.,Zielinski, Z.,Dowiercial, A.,Bzowska, A.,Rode, W.; Molecular Mechanism of Thymidylate Synthase Inhibition by N4-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies; Int J Mol Sci, 22:-, 2021; PubMed: 33946210; DOI: 10.3390/ijms22094758

実験手法

X-RAY DIFFRACTION (2.127 Å)