6F5L

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a inhibitor JHU2379

Summary for 6F5L

Entry DOI	10.2210/pdb6f5l/pdb
Descriptor	Glutamate carboxypeptidase 2, 1,2-ETHANEDIOL, (2~{S})-2-[[(2~{S})-4-methyl-1-oxidanyl-1-oxidanylidene-pentan-2-yl]carbamoyloxy]pentanedioic acid, ... (12 entities in total)
Functional Keywords	glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; phosphoramidate, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	83410.48
Authors	Barinka, C.,Novakova, Z.,Motlova, L. (deposition date: 2017-12-01, release date: 2018-12-12, Last modification date: 2024-01-17)
Primary citation	Barinka, C.,Novakova, Z.,Hin, N.,Bim, D.,Ferraris, D.V.,Duvall, B.,Kabarriti, G.,Tsukamoto, R.,Budesinsky, M.,Motlova, L.,Rojas, C.,Slusher, B.S.,Rokob, T.A.,Rulisek, L.,Tsukamoto, T. Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors. Bioorg.Med.Chem., 27:255-264, 2019 Cited by PubMed: 30552009 DOI: 10.1016/j.bmc.2018.11.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation