6F3I

IRAK4 IN COMPLEX WITH inhibitor

Summary for 6F3I

Entry DOI	10.2210/pdb6f3i/pdb
Descriptor	Interleukin-1 receptor-associated kinase 4, (3~{R})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	irak4, kinase, inhibitor, cancer, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9NWZ3
Total number of polymer chains	2
Total formula weight	74007.31
Authors	Xue, Y.,Degorce, S.L.,Robb, G.R.,Ferguson, A.D. (deposition date: 2017-11-28, release date: 2018-05-23)
Primary citation	Degorce, S.L.,Anjum, R.,Dillman, K.S.,Drew, L.,Groombridge, S.D.,Halsall, C.T.,Lenz, E.M.,Lindsay, N.A.,Mayo, M.F.,Pink, J.H.,Robb, G.R.,Scott, J.S.,Stokes, S.,Xue, Y. Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4. Bioorg. Med. Chem., 26:913-924, 2018 Cited by PubMed: 29398441 DOI: 10.1016/j.bmc.2018.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation