6F28
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2'-Amino-2'-carboxyethyl]-6-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.4A
6F28 の概要
エントリーDOI | 10.2210/pdb6f28/pdb |
分子名称 | Glutamate receptor ionotropic, kainate 3,Glutamate receptor ionotropic, kainate 3, ZINC ION, (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid, ... (6 entities in total) |
機能のキーワード | ionotropic glutamate receptor, gluk3, ligand binding domain, membrane protein., membrane protein |
由来する生物種 | Rattus norvegicus (Rat) 詳細 |
細胞内の位置 | Cell membrane; Multi-pass membrane protein: P42264 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 59222.86 |
構造登録者 | |
主引用文献 | Brogi, S.,Brindisi, M.,Butini, S.,Kshirsagar, G.U.,Maramai, S.,Chemi, G.,Gemma, S.,Campiani, G.,Novellino, E.,Fiorenzani, P.,Pinassi, J.,Aloisi, A.M.,Gynther, M.,Venskutonyte, R.,Han, L.,Frydenvang, K.,Kastrup, J.S.,Pickering, D.S. ( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation. J. Med. Chem., 61:2124-2130, 2018 Cited by PubMed: 29451794DOI: 10.1021/acs.jmedchem.8b00099 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
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