6F0A

Crystal structure of human indoleamine 2,3-dioxygenase bound to a triazole inhibitor and alanine molecule.

Summary for 6F0A

Entry DOI	10.2210/pdb6f0a/pdb
Descriptor	Indoleamine 2,3-dioxygenase 1, ~{N}-(4-chlorophenyl)-1~{H}-1,2,3-triazol-5-amine, ALANINE, ... (5 entities in total)
Functional Keywords	tryptophan 2 3 dioxygenase activity electron transfer activity oxidoreductase activity heme binding indoleamine 2 3 dioxygenase activity metal ion binding dioxygenase activity, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	90248.22
Authors	Swan, M.K.,Latchem, M. (deposition date: 2017-11-17, release date: 2017-12-27, Last modification date: 2024-01-17)
Primary citation	Alexandre, J.A.C.,Swan, M.K.,Latchem, M.J.,Boyall, D.,Pollard, J.R.,Hughes, S.W.,Westcott, J. New 4-Amino-1,2,3-Triazole Inhibitors of Indoleamine 2,3-Dioxygenase Form a Long-Lived Complex with the Enzyme and Display Exquisite Cellular Potency. Chembiochem, 19:552-561, 2018 Cited by PubMed: 29240291 DOI: 10.1002/cbic.201700560 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation