6F0A

Crystal structure of human indoleamine 2,3-dioxygenase bound to a triazole inhibitor and alanine molecule.

6F0A の概要

• エントリーDOI: 10.2210/pdb6f0a/pdb
• 分子名称: Indoleamine 2,3-dioxygenase 1, ~{N}-(4-chlorophenyl)-1~{H}-1,2,3-triazol-5-amine, ALANINE, ... (5 entities in total)
• 機能のキーワード: tryptophan 2 3 dioxygenase activity electron transfer activity oxidoreductase activity heme binding indoleamine 2 3 dioxygenase activity metal ion binding dioxygenase activity, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90248.22

構造登録者

Swan, M.K.,Latchem, M. (登録日: 2017-11-17, 公開日: 2017-12-27, 最終更新日: 2024-01-17)

• 主引用文献: Alexandre, J.A.C.,Swan, M.K.,Latchem, M.J.,Boyall, D.,Pollard, J.R.,Hughes, S.W.,Westcott, J.; New 4-Amino-1,2,3-Triazole Inhibitors of Indoleamine 2,3-Dioxygenase Form a Long-Lived Complex with the Enzyme and Display Exquisite Cellular Potency.; Chembiochem, 19:552-561, 2018; PubMed: 29240291; DOI: 10.1002/cbic.201700560

実験手法

X-RAY DIFFRACTION (2.26 Å)