6EYO
Structure of extended IgE-Fc in complex with two anti-IgE Fabs
Summary for 6EYO
Entry DOI | 10.2210/pdb6eyo/pdb |
Descriptor | Immunoglobulin heavy constant epsilon, 8D6 Fab heavy chain, 8D6 Fab light chain, ... (5 entities in total) |
Functional Keywords | immunoglobulin e, fab, antibody, complex, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 171734.64 |
Authors | Chen, J.B.,Ramadani, F.,Pang, M.O.Y.,Beavil, R.L.,Holdom, M.D.,Mitropoulou, A.N.,Beavil, A.J.,Gould, H.J.,Chang, T.W.,Sutton, B.J.,McDonnell, J.M.,Davies, A.M. (deposition date: 2017-11-13, release date: 2018-08-15, Last modification date: 2024-01-17) |
Primary citation | Chen, J.B.,Ramadani, F.,Pang, M.O.Y.,Beavil, R.L.,Holdom, M.D.,Mitropoulou, A.N.,Beavil, A.J.,Gould, H.J.,Chang, T.W.,Sutton, B.J.,McDonnell, J.M.,Davies, A.M. Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody. Sci Rep, 8:11548-11548, 2018 Cited by PubMed: 30069035DOI: 10.1038/s41598-018-29664-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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