6EXL

The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (MK206) - folded HTH motif

Summary for 6EXL

• Entry DOI: 10.2210/pdb6exl/pdb
• Related: 5F1R
• Descriptor: Listeriolysin positive regulatory factor A, [(3~{R})-3-carboxy-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium, SODIUM ION, ... (5 entities in total)
• Functional Keywords: transcription regulator, dna binding, 2-pyridone, drug design, listeria monocytogenes, dna binding protein
• Biological source: Listeria monocytogenes
• Total number of polymer chains: 2
• Total formula weight: 56047.43

Authors

Hall, M.,Grundstrom, C.,Begum, A.,Kulen, M.,Lindgren, M.,Johansson, J.,Almqvist, F.,Sauer, U.H.,Sauer-Eriksson, A.E. (deposition date: 2017-11-08, release date: 2018-05-02, Last modification date: 2024-01-17)

• Primary citation: Kulen, M.,Lindgren, M.,Hansen, S.,Cairns, A.G.,Grundstrom, C.,Begum, A.,van der Lingen, I.,Brannstrom, K.,Hall, M.,Sauer, U.H.,Johansson, J.,Sauer-Eriksson, A.E.,Almqvist, F.; Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.; J. Med. Chem., 61:4165-4175, 2018; PubMed: 29667825; DOI: 10.1021/acs.jmedchem.8b00289

Experimental method

X-RAY DIFFRACTION (1.9 Å)