6EW7

Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand

Summary for 6EW7

• Entry DOI: 10.2210/pdb6ew7/pdb
• Related: 5N1X 5N1Z 5N20 5N21
• Descriptor: B-cell lymphoma 6 protein, CHLORIDE ION, 2-chloranyl-4-[[5-chloranyl-4-[(4-fluorophenyl)amino]pyrimidin-2-yl]amino]benzoic acid, ... (4 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29058.13

Authors

Robb, G.,Ferguson, A.,Hargreaves, D. (deposition date: 2017-11-03, release date: 2018-10-24, Last modification date: 2018-11-28)

• Primary citation: McCoull, W.,Cheung, T.,Anderson, E.,Barton, P.,Burgess, J.,Byth, K.,Cao, Q.,Castaldi, M.P.,Chen, H.,Chiarparin, E.,Carbajo, R.J.,Code, E.,Cowan, S.,Davey, P.R.,Ferguson, A.D.,Fillery, S.,Fuller, N.O.,Gao, N.,Hargreaves, D.,Howard, M.R.,Hu, J.,Kawatkar, A.,Kemmitt, P.D.,Leo, E.,Molina, D.M.,O'Connell, N.,Petteruti, P.,Rasmusson, T.,Raubo, P.,Rawlins, P.B.,Ricchiuto, P.,Robb, G.R.,Schenone, M.,Waring, M.J.,Zinda, M.,Fawell, S.,Wilson, D.M.; Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.; ACS Chem. Biol., 13:3131-3141, 2018; PubMed: 30335946; DOI: 10.1021/acschembio.8b00698

Experimental method

X-RAY DIFFRACTION (1.6 Å)