6EVQ

solution NMR structure of EB1 C terminus (191-260) with a small molecule bound into the SxIP binding site

6EVQ の概要

• エントリーDOI: 10.2210/pdb6evq/pdb
• 分子名称: Microtubule-associated protein RP/EB family member 1, (2~{R})-2-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)sulfanyl]-~{N}-(furan-2-ylmethyl)propanamide (2 entities in total)
• 機能のキーワード: end-binding protein, eb1, microtubules, sxip, microtubule-associated protein rp/eb family member 1, mapre1, apc-binding protein eb1, protein binding
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16742.75

構造登録者

Barsukov, I.L.,Almeida, T.B. (登録日: 2017-11-02, 公開日: 2018-02-07, 最終更新日: 2024-05-15)

• 主引用文献: Almeida, T.B.,Carnell, A.J.,Barsukov, I.L.,Berry, N.G.; Targeting SxIP-EB1 interaction: An integrated approach to the discovery of small molecule modulators of dynamic binding sites.; Sci Rep, 7:15533-15533, 2017; PubMed: 29138501; DOI: 10.1038/s41598-017-15502-6

実験手法

SOLUTION NMR