6EVO

Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with Pro-Pro-Gly-Pro-Arg-Gly-Pro-Pro-Gly.

6EVO の概要

• エントリーDOI: 10.2210/pdb6evo/pdb
• 関連するPDBエントリー: 6EVL 6EVM 6EVN
• 分子名称: Prolyl 4-hydroxylase subunit alpha-2, PRO-PRO-GLY-PRO-ARG-GLY-PRO-PRO-GLY, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: tetratricopeptide repeat, collagen synthesis, prolyl 4-hydroxylase, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 13178.73

構造登録者

Murthy, A.V.,Sulu, R.,Koski, M.K.,Wierenga, R.K. (登録日: 2017-11-02, 公開日: 2018-09-12, 最終更新日: 2024-05-08)

• 主引用文献: Murthy, A.V.,Sulu, R.,Koski, M.K.,Tu, H.,Anantharajan, J.,Sah-Teli, S.K.,Myllyharju, J.,Wierenga, R.K.; Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.; Protein Sci., 27:1692-1703, 2018; PubMed: 30168208; DOI: 10.1002/pro.3450

実験手法

X-RAY DIFFRACTION (1.55 Å)