6EVO

Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with Pro-Pro-Gly-Pro-Arg-Gly-Pro-Pro-Gly.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Prolyl 4-hydroxylase subunit alpha-2	polymer	102	11920.3	1	UniProt (O15460)	Homo sapiens (Human)	4-PH alpha-2,Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
2	B (C)	PRO-PRO-GLY-PRO-ARG-GLY-PRO-PRO-GLY	polymer	9	831.9	1		synthetic construct
3	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E, F, G (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
5	H, I (A, C)	water	water		18.0	82	Chemie (HOH)

Sequence modifications

A: 144 - 238 (UniProt: O15460)

PDB	External Database	Details
Met 137	-	initiating methionine
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	12752.2
Non-Polymers*	Number of molecules	5
	Total formula weight	426.5
All*	Total formula weight	13178.7

*Water molecules are not included.