6EVL

Crystal structure of an unlignaded peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase

Summary for 6EVL

Entry DOI	10.2210/pdb6evl/pdb
Descriptor	Prolyl 4-hydroxylase subunit alpha-2, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	tetratricopeptide repeat, collagen synthesis, prolyl 4-hydroxylase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	12244.60
Authors	Murthy, A.V.,Sulu, R.,Koski, M.K.,Wierenga, R.K. (deposition date: 2017-11-02, release date: 2018-09-12, Last modification date: 2024-01-17)
Primary citation	Murthy, A.V.,Sulu, R.,Koski, M.K.,Tu, H.,Anantharajan, J.,Sah-Teli, S.K.,Myllyharju, J.,Wierenga, R.K. Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci., 27:1692-1703, 2018 Cited by PubMed: 30168208 DOI: 10.1002/pro.3450 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation