6EUY
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Summary for 6EUY
Entry DOI | 10.2210/pdb6euy/pdb |
Descriptor | Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, SULFATE ION (3 entities in total) |
Functional Keywords | influenza a polymerase pb2 subunit cap-binding domain cap-binding inhibitor, rna binding protein |
Biological source | Influenza A virus (A/Victoria/3/1975(H3N2)) |
Cellular location | Virion : P31345 |
Total number of polymer chains | 3 |
Total formula weight | 99350.49 |
Authors | Cusack, S.,Gaudon, S. (deposition date: 2017-10-31, release date: 2017-12-13, Last modification date: 2024-01-17) |
Primary citation | Pflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S. Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46:956-971, 2018 Cited by PubMed: 29202182DOI: 10.1093/nar/gkx1210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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