6EUW

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor

6EUW の概要

• エントリーDOI: 10.2210/pdb6euw/pdb
• 分子名称: Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: influenza rna-dependent rna polymerase, pb2 subunit, cap-binding domain, inhibitor, rna binding protein
• 由来する生物種: Influenza A virus (A/duck/Shantou/4610/2003(H5N1))
• 細胞内の位置: Host nucleus : Q2LG68
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18832.77

構造登録者

Cusack, S.,Gaudon, S. (登録日: 2017-10-31, 公開日: 2017-12-13, 最終更新日: 2024-01-17)

• 主引用文献: Pflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S.; Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.; Nucleic Acids Res., 46:956-971, 2018; PubMed: 29202182; DOI: 10.1093/nar/gkx1210

実験手法

X-RAY DIFFRACTION (1 Å)