6EUU
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (KSK29)
Summary for 6EUU
| Entry DOI | 10.2210/pdb6euu/pdb |
| Related | 5F1R 6EUT |
| Descriptor | Listeriolysin positive regulatory factor A, SODIUM ION, ISOPROPYL ALCOHOL, ... (5 entities in total) |
| Functional Keywords | transcription regulator, dna binding, 2-pyridone, drug design, listeria monocytogenes, dna binding protein |
| Biological source | Listeria monocytogenes |
| Total number of polymer chains | 2 |
| Total formula weight | 55579.85 |
| Authors | Begum, A.,Hall, M.,Grundstrom, C.,Kulen, M.,Lindgren, M.,Johansson, J.,Almqvist, F.,Sauer, U.H.,Sauer-Eriksson, A.E. (deposition date: 2017-10-31, release date: 2018-05-02, Last modification date: 2024-01-17) |
| Primary citation | Kulen, M.,Lindgren, M.,Hansen, S.,Cairns, A.G.,Grundstrom, C.,Begum, A.,van der Lingen, I.,Brannstrom, K.,Hall, M.,Sauer, U.H.,Johansson, J.,Sauer-Eriksson, A.E.,Almqvist, F. Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes. J. Med. Chem., 61:4165-4175, 2018 Cited by PubMed: 29667825DOI: 10.1021/acs.jmedchem.8b00289 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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