6ES1

Crystal structure of the binding domain from botulinum neurotoxin A2 bound to extracellular domain of human receptor SV2C

6ES1 の概要

• エントリーDOI: 10.2210/pdb6es1/pdb
• 分子名称: Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: receptor, human, clostridium botulinum, binding domain, sv2c, protein binding
• 由来する生物種: Clostridium botulinum; 詳細
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: Q45894; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi- pass membrane protein : Q496J9
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65580.88

構造登録者

Gustafsson, R.,Masuyer, G.,Stenmark, P. (登録日: 2017-10-19, 公開日: 2018-04-25, 最終更新日: 2024-01-17)

• 主引用文献: Gustafsson, R.,Zhang, S.,Masuyer, G.,Dong, M.,Stenmark, P.; Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.; Toxins (Basel), 10:-, 2018; PubMed: 29649119; DOI: 10.3390/toxins10040153

実験手法

X-RAY DIFFRACTION (2 Å)