6ES0

Crystal structure of the kinase domain of human RIPK2 in complex with the activation loop targeting inhibitor CS-R35

6ES0 の概要

• エントリーDOI: 10.2210/pdb6es0/pdb
• 分子名称: Receptor-interacting serine/threonine-protein kinase 2, 2-[2-fluoranyl-4-[[2-fluoranyl-4-[2-(methylcarbamoyl)pyridin-4-yl]oxy-phenyl]carbamoylamino]phenyl]sulfanylethanoic acid (3 entities in total)
• 機能のキーワード: kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73748.63

構造登録者

Pinkas, D.M.,Bufton, J.C.,Suebsuwong, C.,Ray, S.S.,Dai, B.,Newman, J.A.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Degterev, A.,Cuny, G.D.,Bullock, A.N. (登録日: 2017-10-19, 公開日: 2018-02-21, 最終更新日: 2024-01-17)

• 主引用文献: Suebsuwong, C.,Pinkas, D.M.,Ray, S.S.,Bufton, J.C.,Dai, B.,Bullock, A.N.,Degterev, A.,Cuny, G.D.; Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors.; Bioorg. Med. Chem. Lett., 28:577-583, 2018; PubMed: 29409752; DOI: 10.1016/j.bmcl.2018.01.044

実験手法

X-RAY DIFFRACTION (2.38 Å)