6EQV

X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Phac-Cit-Val-Arg-Amba

6EQV の概要

• エントリーDOI: 10.2210/pdb6eqv/pdb
• 分子名称: Furin, HY1-LLI-VAL-ARG-00S, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: protease, inhibitor, complex, proprotein convertase, citrullin, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane ; Single- pass type I membrane protein : P09958
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53301.07

構造登録者

Dahms, S.O.,Than, M.E. (登録日: 2017-10-16, 公開日: 2018-02-28, 最終更新日: 2024-01-17)

• 主引用文献: Dahms, S.O.,Hardes, K.,Steinmetzer, T.,Than, M.E.; X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.; Biochemistry, 57:925-934, 2018; PubMed: 29314830; DOI: 10.1021/acs.biochem.7b01124

実験手法

X-RAY DIFFRACTION (1.895 Å)