6EO0

Zebrafish Sirt5 in complex with stalled peptidylimidate and bicyclic intermediate of inhibitory compound 29

6EO0 の概要

• エントリーDOI: 10.2210/pdb6eo0/pdb
• 分子名称: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: hydrolase, ptm, inhibitor, signaling protein
• 由来する生物種: Danio rerio (Zebrafish)
• 細胞内の位置: Mitochondrion : Q6DHI5
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129146.92

構造登録者

Pannek, M.,Steegborn, C. (登録日: 2017-10-08, 公開日: 2017-11-01, 最終更新日: 2024-01-17)

• 主引用文献: Rajabi, N.,Auth, M.,Troelsen, K.R.,Pannek, M.,Bhatt, D.P.,Fontenas, M.,Hirschey, M.D.,Steegborn, C.,Madsen, A.S.,Olsen, C.A.; Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.; Angew. Chem. Int. Ed. Engl., 56:14836-14841, 2017; PubMed: 29044784; DOI: 10.1002/anie.201709050

実験手法

X-RAY DIFFRACTION (2.4 Å)