6ELI

Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462

6ELI の概要

• エントリーDOI: 10.2210/pdb6eli/pdb
• 関連するPDBエントリー: 4G1Q
• 分子名称: reverse transcriptase, Gag-Pol polyprotein, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (8 entities in total)
• 機能のキーワード: p51/p66, hetero dimer, nnrti, ribonuclease h inhibitor, nonnucleoside inhibitor, aids, hiv, r278474, diarylpyrimidine, dapy, dna recombination, dna polymerase, endonuclease, hydrolase, multifunctional, enzyme, transferase, hydrolase-inhibitor complex
• 由来する生物種: Human immunodeficiency virus type 1 BH10; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115049.35

構造登録者

Das, K.,Arnold, E. (登録日: 2017-09-29, 公開日: 2018-04-11, 最終更新日: 2024-01-17)

• 主引用文献: Boyer, P.L.,Smith, S.J.,Zhao, X.Z.,Das, K.,Gruber, K.,Arnold, E.,Burke, T.R.,Hughes, S.H.; Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase.; J. Virol., 92:-, 2018; PubMed: 29643235; DOI: 10.1128/JVI.02203-17

実験手法