6EL9
Glucocorticoid Receptor in complex with AZD9567
Summary for 6EL9
Entry DOI | 10.2210/pdb6el9/pdb |
Related | 6EL7 |
Descriptor | Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | glucocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150 Nucleus: Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 34295.50 |
Authors | Edman, K.,Wissler, L. (deposition date: 2017-09-28, release date: 2018-02-21, Last modification date: 2024-01-17) |
Primary citation | Ripa, L.,Edman, K.,Dearman, M.,Edenro, G.,Hendrickx, R.,Ullah, V.,Chang, H.F.,Lepisto, M.,Chapman, D.,Geschwindner, S.,Wissler, L.,Svanberg, P.,Lawitz, K.,Malmberg, J.,Nikitidis, A.,Olsson, R.I.,Bird, J.,Llinas, A.,Hegelund-Myrback, T.,Berger, M.,Thorne, P.,Harrison, R.,Kohler, C.,Drmota, T. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J. Med. Chem., 61:1785-1799, 2018 Cited by PubMed: 29424542DOI: 10.1021/acs.jmedchem.7b01690 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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