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6EL7

Glucocorticoid Receptor in complex with compound 31

Summary for 6EL7
Entry DOI10.2210/pdb6el7/pdb
Related6EL6
DescriptorGlucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsglucocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, signaling protein
Biological sourceHomo sapiens (Human)
More
Cellular locationIsoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150
Nucleus: Q15596
Total number of polymer chains2
Total formula weight34266.26
Authors
Edman, K.,Wissler, L. (deposition date: 2017-09-28, release date: 2018-02-21, Last modification date: 2024-01-17)
Primary citationRipa, L.,Edman, K.,Dearman, M.,Edenro, G.,Hendrickx, R.,Ullah, V.,Chang, H.F.,Lepisto, M.,Chapman, D.,Geschwindner, S.,Wissler, L.,Svanberg, P.,Lawitz, K.,Malmberg, J.,Nikitidis, A.,Olsson, R.I.,Bird, J.,Llinas, A.,Hegelund-Myrback, T.,Berger, M.,Thorne, P.,Harrison, R.,Kohler, C.,Drmota, T.
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61:1785-1799, 2018
Cited by
PubMed: 29424542
DOI: 10.1021/acs.jmedchem.7b01690
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.18 Å)
Structure validation

217705

건을2024-03-27부터공개중

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