6EJG

CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 4

Summary for 6EJG

Related5DFW
DescriptorCD81 antigen, SINGLE CHAIN FV FRAGMENT (3 entities in total)
Functional Keywordshelical bundle, antibody-antigen complex, cell adhesion
Biological sourceHomo sapiens (Human)
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Total number of polymer chains4
Total molecular weight74642.96
Authors
Harris, S.F.,Wong, A.,Kuglstatter, A. (deposition date: 2017-09-21, release date: 2018-05-30, Last modification date: 2018-06-20)
Primary citation
Nelson, B.,Adams, J.,Kuglstatter, A.,Li, Z.,Harris, S.F.,Liu, Y.,Bohini, S.,Ma, H.,Klumpp, K.,Gao, J.,Sidhu, S.S.
Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.
J. Mol. Biol., 430:2139-2152, 2018
PubMed: 29778602 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2018.05.018
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267101.3%5.3%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report