6EJ3
BACE1 compound 23
Summary for 6EJ3
Entry DOI | 10.2210/pdb6ej3/pdb |
Related | 6EJ2 |
Descriptor | Beta-secretase 1, (1r,4r)-4-methoxy-6'-(5-methyl-3-pyridinyl)-3'H-dispiro[cyclohexane-1,2'-indene-1',4''-[1,3]oxazol]-2''-amine (3 entities in total) |
Functional Keywords | bace1, protease, alzheimer, peptide binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 56192.97 |
Authors | Johansson, P. (deposition date: 2017-09-20, release date: 2018-04-18, Last modification date: 2024-05-01) |
Primary citation | Johansson, P.,Kaspersson, K.,Gurrell, I.K.,Back, E.,Eketjall, S.,Scott, C.W.,Cebers, G.,Thorne, P.,McKenzie, M.J.,Beaton, H.,Davey, P.,Kolmodin, K.,Holenz, J.,Duggan, M.E.,Budd Haeberlein, S.,Burli, R.W. Toward beta-Secretase-1 Inhibitors with Improved Isoform Selectivity. J. Med. Chem., 61:3491-3502, 2018 Cited by PubMed: 29617572DOI: 10.1021/acs.jmedchem.7b01716 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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