6EI4
Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site
Summary for 6EI4
Entry DOI | 10.2210/pdb6ei4/pdb |
Descriptor | Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone, COPPER (II) ION, ... (4 entities in total) |
Functional Keywords | tyrosinase, inhibitor, ligand, oxidoreductase |
Biological source | Bacillus megaterium |
Total number of polymer chains | 2 |
Total formula weight | 67771.87 |
Authors | Deri, B.,Gitto, R.,Pazy Benhar, Y.,Fishman, A. (deposition date: 2017-09-17, release date: 2018-04-25, Last modification date: 2024-01-17) |
Primary citation | Ferro, S.,Deri, B.,Germano, M.P.,Gitto, R.,Ielo, L.,Buemi, M.R.,Certo, G.,Vittorio, S.,Rapisarda, A.,Pazy, Y.,Fishman, A.,De Luca, L. Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61:3908-3917, 2018 Cited by PubMed: 29634898DOI: 10.1021/acs.jmedchem.7b01745 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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