6EI4

Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site

6EI4 の概要

• エントリーDOI: 10.2210/pdb6ei4/pdb
• 分子名称: Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone, COPPER (II) ION, ... (4 entities in total)
• 機能のキーワード: tyrosinase, inhibitor, ligand, oxidoreductase
• 由来する生物種: Bacillus megaterium
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67771.87

構造登録者

Deri, B.,Gitto, R.,Pazy Benhar, Y.,Fishman, A. (登録日: 2017-09-17, 公開日: 2018-04-25, 最終更新日: 2024-01-17)

• 主引用文献: Ferro, S.,Deri, B.,Germano, M.P.,Gitto, R.,Ielo, L.,Buemi, M.R.,Certo, G.,Vittorio, S.,Rapisarda, A.,Pazy, Y.,Fishman, A.,De Luca, L.; Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.; J. Med. Chem., 61:3908-3917, 2018; PubMed: 29634898; DOI: 10.1021/acs.jmedchem.7b01745

実験手法

X-RAY DIFFRACTION (2 Å)