6EGF
Crystal structure of the inactive unphosphorylated IRAK4 kinase domain bound to AMP-PNP
Summary for 6EGF
Entry DOI | 10.2210/pdb6egf/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... (5 entities in total) |
Functional Keywords | kinase, unphosphorylated, inactive, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34438.95 |
Authors | Ferrao, R.,Wu, H. (deposition date: 2018-08-19, release date: 2019-02-13, Last modification date: 2024-03-13) |
Primary citation | Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294:4511-4519, 2019 Cited by PubMed: 30679311DOI: 10.1074/jbc.RA118.005428 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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