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6EGF

Crystal structure of the inactive unphosphorylated IRAK4 kinase domain bound to AMP-PNP

Summary for 6EGF
Entry DOI10.2210/pdb6egf/pdb
DescriptorInterleukin-1 receptor-associated kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... (5 entities in total)
Functional Keywordskinase, unphosphorylated, inactive, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34438.95
Authors
Ferrao, R.,Wu, H. (deposition date: 2018-08-19, release date: 2019-02-13, Last modification date: 2024-03-13)
Primary citationWang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H.
Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294:4511-4519, 2019
Cited by
PubMed: 30679311
DOI: 10.1074/jbc.RA118.005428
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.61 Å)
Structure validation

217705

건을2024-03-27부터공개중

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