6EGA

IRAK4 in complex with a type II inhibitor

6EGA の概要

• エントリーDOI: 10.2210/pdb6ega/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71349.88

構造登録者

Wang, L.,Wu, H. (登録日: 2018-08-19, 公開日: 2019-02-20, 最終更新日: 2024-03-13)

• 主引用文献: Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H.; Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).; J.Biol.Chem., 294:4511-4519, 2019; PubMed: 30679311; DOI: 10.1074/jbc.RA118.005428

実験手法

X-RAY DIFFRACTION (2.512 Å)