6EG2

Crystal structure of human BRM in complex with compound 16

6EG2 の概要

• エントリーDOI: 10.2210/pdb6eg2/pdb
• 分子名称: Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea, ISOPROPYL ALCOHOL, ... (4 entities in total)
• 機能のキーワード: helicase, atpase, chromatin remodeling, inhibitor, mbp fusion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli O157:H7; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 70251.99

構造登録者

Zhu, X.,Kulathila, R.,Hu, T.,Xie, X. (登録日: 2018-08-17, 公開日: 2018-10-31, 最終更新日: 2023-10-11)

• 主引用文献: Papillon, J.P.N.,Nakajima, K.,Adair, C.D.,Hempel, J.,Jouk, A.O.,Karki, R.G.,Mathieu, S.,Mobitz, H.,Ntaganda, R.,Smith, T.,Visser, M.,Hill, S.E.,Hurtado, F.K.,Chenail, G.,Bhang, H.C.,Bric, A.,Xiang, K.,Bushold, G.,Gilbert, T.,Vattay, A.,Dooley, J.,Costa, E.A.,Park, I.,Li, A.,Farley, D.,Lounkine, E.,Yue, Q.K.,Xie, X.,Zhu, X.,Kulathila, R.,King, D.,Hu, T.,Vulic, K.,Cantwell, J.,Luu, C.,Jagani, Z.; Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.; J. Med. Chem., 61:10155-10172, 2018; PubMed: 30339381; DOI: 10.1021/acs.jmedchem.8b01318

実験手法

X-RAY DIFFRACTION (2.98 Å)