6EE3

X-ray crystal structure of Pf-M1 in complex with inhibitor (6k) and catalytic zinc ion

6EE3 の概要

• エントリーDOI: 10.2210/pdb6ee3/pdb
• 分子名称: M1 family aminopeptidase, ZINC ION, (1R,2r,3S,5R,7R)-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]tricyclo[3.3.1.1~3,7~]decane-2-carboxamide, ... (7 entities in total)
• 機能のキーワード: m1 alanyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum (isolate FcB1 / Columbia)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 104531.87

構造登録者

Drinkwater, N.,McGowan, S. (登録日: 2018-08-13, 公開日: 2018-12-26, 最終更新日: 2024-03-13)

• 主引用文献: Vinh, N.B.,Drinkwater, N.,Malcolm, T.R.,Kassiou, M.,Lucantoni, L.,Grin, P.M.,Butler, G.S.,Duffy, S.,Overall, C.M.,Avery, V.M.,Scammells, P.J.,McGowan, S.; Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.; J. Med. Chem., 62:622-640, 2019; PubMed: 30537832; DOI: 10.1021/acs.jmedchem.8b01310

実験手法

X-RAY DIFFRACTION (1.82 Å)