6ECQ

The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY345899

Summary for 6ECQ

Entry DOI	10.2210/pdb6ecq/pdb
Descriptor	METHYLENETETRAHYDROFOLATE DEHYDROGENASE CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-{4-[(6aR)-3-amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzene-1-carbonyl}-L-glutamic acid, ... (4 entities in total)
Functional Keywords	dehydrogenase, cyclohydrolase, bifunctional protein, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	66139.93
Authors	Bueno, R.V.,Dawson, A.,Hunter, W.N. (deposition date: 2018-08-08, release date: 2019-03-27, Last modification date: 2023-10-11)
Primary citation	Bueno, R.,Dawson, A.,Hunter, W.N. An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement. Acta Crystallogr F Struct Biol Commun, 75:148-152, 2019 Cited by PubMed: 30839287 DOI: 10.1107/S2053230X18018083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation