6ECQ

The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY345899

6ECQ の概要

• エントリーDOI: 10.2210/pdb6ecq/pdb
• 分子名称: METHYLENETETRAHYDROFOLATE DEHYDROGENASE CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-{4-[(6aR)-3-amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzene-1-carbonyl}-L-glutamic acid, ... (4 entities in total)
• 機能のキーワード: dehydrogenase, cyclohydrolase, bifunctional protein, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66139.93

構造登録者

Bueno, R.V.,Dawson, A.,Hunter, W.N. (登録日: 2018-08-08, 公開日: 2019-03-27, 最終更新日: 2023-10-11)

• 主引用文献: Bueno, R.,Dawson, A.,Hunter, W.N.; An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement.; Acta Crystallogr F Struct Biol Commun, 75:148-152, 2019; PubMed: 30839287; DOI: 10.1107/S2053230X18018083

実験手法

X-RAY DIFFRACTION (2.7 Å)