6ECD
Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a tetradepsipeptide
Summary for 6ECD
Entry DOI | 10.2210/pdb6ecd/pdb |
Related | 6ECB 6ECC 6ECE 6ECF |
Descriptor | Vlm2, tetradepsipeptide (3 entities in total) |
Functional Keywords | thioesterase, thioesterase domain, nrps, non-ribosomal peptide synthetase, nonribosomal peptide synthetase, valinomycin, hydrolase, depsipeptide, unnatural amino acid, 2, 3-diaminopropionic acid |
Biological source | Streptomyces tsusimaensis More |
Total number of polymer chains | 2 |
Total formula weight | 33483.97 |
Authors | Alonzo, D.A.,Huguenin-Dezot, N.,Heberlig, G.W.,Mahesh, M.,Nguyen, D.P.,Dornan, M.H.,Boddy, C.N.,Chin, J.W.,Schmeing, T.M. (deposition date: 2018-08-07, release date: 2018-12-12, Last modification date: 2023-11-15) |
Primary citation | Huguenin-Dezot, N.,Alonzo, D.A.,Heberlig, G.W.,Mahesh, M.,Nguyen, D.P.,Dornan, M.H.,Boddy, C.N.,Schmeing, T.M.,Chin, J.W. Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature, 565:112-117, 2019 Cited by PubMed: 30542153DOI: 10.1038/s41586-018-0781-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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