6EAD

CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT F140I STABILIZED IN THE PREFUSION STATE

Summary for 6EAD

DescriptorFusion glycoprotein F0, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ... (5 entities in total)
Functional Keywordsclass i viral fusion protein, fusion, respiratory syncytial virus, prefusion, viral protein, fusion inhibitor
Biological sourceHuman respiratory syncytial virus
Total number of polymer chains1
Total molecular weight64565.68
Authors
Battles, M.B.,McLellan, J.S. (deposition date: 2018-08-03, release date: 2019-08-07)
Primary citation
Battles, M.B.,McLellan, J.S.
Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published,
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23130 0.5% 3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution