6EA9

Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']

Summary for 6EA9

Entry DOI	10.2210/pdb6ea9/pdb
Descriptor	Protein B2, 2',5'-GpAp (3 entities in total)
Functional Keywords	vaccina virus, nuclease, cgas, cgamp, poxvirus, innate immunity, hydrolase
Biological source	Vaccinia virus WR (VACV)
Total number of polymer chains	5
Total formula weight	127178.27
Authors	Eaglesham, J.B.,Kranzusch, P.J. (deposition date: 2018-08-02, release date: 2019-02-06, Last modification date: 2024-03-13)
Primary citation	Eaglesham, J.B.,Pan, Y.,Kupper, T.S.,Kranzusch, P.J. Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature, 566:259-263, 2019 Cited by PubMed: 30728498 DOI: 10.1038/s41586-019-0928-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation