6E6E

DGY-06-116, a novel and selective covalent inhibitor of SRC kinase

Summary for 6E6E

• Entry DOI: 10.2210/pdb6e6e/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide (3 entities in total)
• Functional Keywords: proto-oncogene tyrosine-protein kinase src, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 258043.85

Authors

Gurbani, D.,Bera, A.,Westover, K. (deposition date: 2018-07-24, release date: 2019-07-31, Last modification date: 2023-10-11)

• Primary citation: Gurbani, D.,Du, G.,Henning, N.J.,Rao, S.,Bera, A.K.,Zhang, T.,Gray, N.S.,Westover, K.D.; Structure and Characterization of a Covalent Inhibitor of Src Kinase.; Front Mol Biosci, 7:81-81, 2020; PubMed: 32509799; DOI: 10.3389/fmolb.2020.00081

Experimental method

X-RAY DIFFRACTION (2.15 Å)