6E5V

human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)

Summary for 6E5V

Entry DOI	10.2210/pdb6e5v/pdb
Descriptor	Metabotropic glutamate receptor 8, 4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	mglur8 atd, grm8, dcpg, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	118214.70
Authors	Chen, Q.,Ho, J.D.,Ashok, S.,Vargas, M.C.,Wang, J.,Atwell, S.,Bures, M.,Schkeryantz, J.M.,Monn, J.A.,Hao, J. (deposition date: 2018-07-23, release date: 2018-11-07, Last modification date: 2023-10-11)
Primary citation	Chen, Q.,Ho, J.D.,Ashok, S.,Vargas, M.C.,Wang, J.,Atwell, S.,Bures, M.,Schkeryantz, J.M.,Monn, J.A.,Hao, J. Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8Receptor. J. Med. Chem., 61:10040-10052, 2018 Cited by PubMed: 30365309 DOI: 10.1021/acs.jmedchem.8b01120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation