6E5P

Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03

Summary for 6E5P

• Entry DOI: 10.2210/pdb6e5p/pdb
• EMDB information: 8981
• Related PRD ID: PRD_900111
• Descriptor: 2G12 Light chain, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2G12 heavy chain, ... (10 entities in total)
• Functional Keywords: hiv-1 env, complex, neutralizing, viral protein, domain-swapped antibody
• Biological source: Homo sapiens; More
• Total number of polymer chains: 24
• Total formula weight: 658135.30

Authors

Acharya, P.,Kwong, P.D. (deposition date: 2018-07-21, release date: 2019-02-13, Last modification date: 2024-03-13)

• Primary citation: Chuang, G.Y.,Zhou, J.,Acharya, P.,Rawi, R.,Shen, C.H.,Sheng, Z.,Zhang, B.,Zhou, T.,Bailer, R.T.,Dandey, V.P.,Doria-Rose, N.A.,Louder, M.K.,McKee, K.,Mascola, J.R.,Shapiro, L.,Kwong, P.D.; Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.; Structure, 27:196-206.e6, 2019; PubMed: 30471922; DOI: 10.1016/j.str.2018.10.007

Experimental method

ELECTRON MICROSCOPY (8.8 Å)