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6E5P

Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03

Functional Information from GO Data
ChainGOidnamespacecontents
A0019031cellular_componentviral envelope
B0005198molecular_functionstructural molecule activity
C0019031cellular_componentviral envelope
D0005198molecular_functionstructural molecule activity
E0019031cellular_componentviral envelope
F0005198molecular_functionstructural molecule activity
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
1TYR192-HIS198
ITYR190-HIS196
2TYR206-HIS212
JTYR192-HIS198

site_idPS00387
Number of Residues7
DetailsPPASE Inorganic pyrophosphatase signature. DNDPFDA
ChainResidueDetails
2ASP100-ALA102

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PDB entries from 2026-02-18

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