6E5B

Human Immunoproteasome 20S particle in complex with compound 1

6E5B の概要

• エントリーDOI: 10.2210/pdb6e5b/pdb
• 分子名称: Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-8, ... (18 entities in total)
• 機能のキーワード: multicatalytic proteinase, 20s proteasome, protease, proteros, proteros biostructures gmbh, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 761477.64

構造登録者

Steinbacher, S.,Augustin, M.,Blaesse, M.,Harris, S.F. (登録日: 2018-07-19, 公開日: 2019-09-11)

• 主引用文献: Ladi, E.,Everett, C.,Stivala, C.E.,Daniels, B.E.,Durk, M.R.,Harris, S.F.,Huestis, M.P.,Purkey, H.E.,Staben, S.T.,Augustin, M.,Blaesse, M.,Steinbacher, S.,Eidenschenk, C.,Pappu, R.,Siu, M.; Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability.; J.Med.Chem., 62:7032-7041, 2019; PubMed: 31283222; DOI: 10.1021/acs.jmedchem.9b00509

実験手法

X-RAY DIFFRACTION (2.77 Å)