6E4L

The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9

Summary for 6E4L

Entry DOI	10.2210/pdb6e4l/pdb
Descriptor	Clathrin heavy chain 1, DIMETHYL SULFOXIDE, GLYCEROL, ... (7 entities in total)
Functional Keywords	clathrin-mediated endocytosis (cme), clathrin n-terminal domain (ntd), chemical inhibition, endocytosis
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41973.87
Authors	Dejonghe, W.,Sharma, I.,Denoo, B.,Munck, S.D.,Bulut, H.,Mylle, E.,Vasileva, M.,Lu, Q.,Savatin, D.V.,Mishev, K.,Nerinckx, W.,Staes, A.,Drozdzecki, A.,Audenaert, D.,Madder, A.,Friml, J.,Damme, D.V.,Gevaert, K.,Haucke, V.,Savvides, S.,Winne, J.,Russinova, E. (deposition date: 2018-07-17, release date: 2019-04-24, Last modification date: 2023-10-11)
Primary citation	Dejonghe, W.,Sharma, I.,Denoo, B.,De Munck, S.,Lu, Q.,Mishev, K.,Bulut, H.,Mylle, E.,De Rycke, R.,Vasileva, M.,Savatin, D.V.,Nerinckx, W.,Staes, A.,Drozdzecki, A.,Audenaert, D.,Yperman, K.,Madder, A.,Friml, J.,Van Damme, D.,Gevaert, K.,Haucke, V.,Savvides, S.N.,Winne, J.,Russinova, E. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat.Chem.Biol., 15:641-649, 2019 Cited by PubMed: 31011214 DOI: 10.1038/s41589-019-0262-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation