6E4A
Crystal structure of human BRD4(1) in complex with CN750
Summary for 6E4A
Entry DOI | 10.2210/pdb6e4a/pdb |
Descriptor | Bromodomain-containing protein 4, 5-(4-{[(3-chlorophenyl)methyl]amino}-2-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinazolin-6-yl)-1-methylpyridin-2(1H)-one, GLYCEROL, ... (4 entities in total) |
Functional Keywords | brd4(bd1), protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31999.64 |
Authors | Fontano, E.,White, A.,Lakshminarasimhan, D.,Suto, R.K. (deposition date: 2018-07-17, release date: 2018-09-12, Last modification date: 2024-03-13) |
Primary citation | Yang, S.M.,Urban, D.J.,Yoshioka, M.,Strovel, J.W.,Fletcher, S.,Wang, A.Q.,Xu, X.,Shah, P.,Hu, X.,Hall, M.D.,Jadhav, A.,Maloney, D.J. Discovery and lead identification of quinazoline-based BRD4 inhibitors. Bioorg. Med. Chem. Lett., 28:3483-3488, 2018 Cited by PubMed: 30268702DOI: 10.1016/j.bmcl.2018.08.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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