6E3G

Structure of RORgt in complex with a novel agonist.

6E3G の概要

• エントリーDOI: 10.2210/pdb6e3g/pdb
• 分子名称: Nuclear receptor ROR-gamma, co-activator peptide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: nuclear hormone receptor, agonist, nuclear protein, nuclear protein-agonist complex, nuclear protein/agonist
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 60229.96

構造登録者

Skene, R.J.,Hoffman, I. (登録日: 2018-07-13, 公開日: 2019-06-12, 最終更新日: 2024-03-13)

• 主引用文献: Yukawa, T.,Nara, Y.,Kono, M.,Sato, A.,Oda, T.,Takagi, T.,Sato, T.,Banno, Y.,Taya, N.,Imada, T.,Shiokawa, Z.,Negoro, N.,Kawamoto, T.,Koyama, R.,Uchiyama, N.,Skene, R.,Hoffman, I.,Chen, C.H.,Sang, B.,Snell, G.,Katsuyama, R.,Yamamoto, S.,Shirai, J.; Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist.; J.Med.Chem., 62:1167-1179, 2019; PubMed: 30652849; DOI: 10.1021/acs.jmedchem.8b01181

実験手法

X-RAY DIFFRACTION (2.1 Å)