6E2J

Crystal structure of the heterocomplex between human keratin 1 coil 1B containing S233L mutation and wild-type human keratin 10 coil 1B

Summary for 6E2J

DescriptorKeratin, type II cytoskeletal 1, Keratin, type I cytoskeletal 10, SULFATE ION, ... (4 entities in total)
Functional Keywordsintermediate filament, keratin, coiled-coil, skin, protein fibril
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight25296.06
Authors
Eldirany, S.A.,Lomakin, I.B.,Bunick, C.G. (deposition date: 2018-07-11, release date: 2019-05-15)
Primary citation
Eldirany, S.A.,Ho, M.,Hinbest, A.J.,Lomakin, I.B.,Bunick, C.G.
Human keratin 1/10-1B tetramer structures reveal a knob-pocket mechanism in intermediate filament assembly.
Embo J., 2019
PubMed: 31036554 (PDB entries with the same primary citation)
DOI: 10.15252/embj.2018100741
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.386 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.29550 3.1% 13.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 6e2j
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Molmil generated image of 6e2j
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Molmil generated image of 6e2j
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6e2j.pdb1.gz [223.1 KB])
Coordinate files for Biological unit (6e2j.pdb2.gz [445.12 KB])